Mus musculusGenAge entry for Col1a1 (Mus musculus)

Gene information (ID: 2009)

Symbol
Col1a1
Name
collagen, type I, alpha 1
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Mice with a mutation in the Col1a1 gene, that yields collagenase-resistant type I collagen, display a shortened lifespan, when compared with wild-type littermates, and develop features of premature aging (including kyphosis, weight loss, decreased bone mineral density, and hypertension).
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge microarray genes
    • A homolog of this gene for Homo sapiens is present as COL1A1

    Homologs in other organisms

    Danio rerio
    col1a1a
    Homo sapiens
    COL1A1
    Rattus norvegicus
    Col1a1

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (12842)
    Homologues
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    UniProt
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    Internet
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