Drosophila melanogasterGenAge entry for Men (Drosophila melanogaster)

Gene information (ID: 1979)

Symbol
Men
Aliases
anon-WO0118547.278; CG10120; Dmel\CG10120; MDH; Mdh-NA
Name
Malic enzyme
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Ubiquitous and constitutive overexpression of the malic enzyme (Men), during the larval period, extends the maximum lifespan of fruit flies by 24% in males and by 39% in females. Contrastly, Men overexpression in the adult abdominal fat body does not affect lifespan.
% change in max lifespan
Male maximum lifespan is 24% higher. Female maximum lifespan is 39% higher.
% change in avg or median lifespan
Median lifespan is approximately 45% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenDR gene manipulations
    • This gene is present as Men

    Homologs in other organisms

    Caenorhabditis elegans
    men-1
    Danio rerio
    uncharacterized_H9GX
    Homo sapiens
    ME1
    Mus musculus
    Me1
    Rattus norvegicus
    Me3

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (47173)
    Homologues
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    UniProt
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    Internet
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