Caenorhabditis elegansGenAge entry for alh-6 (Caenorhabditis elegans)

Gene information (ID: 1977)

Symbol
alh-6
Name
ALdehyde deHydrogenase
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
RNA interference or mutations in ALH-6 results in a shortened lifespan by up to 40%. This effect is however diet-specific and can be observed when animals are raised on the standard laboratory E. coli OP50 diet or when fed BL21, but not when fed HT115 or HMS174 (with an intermediate effect on a HB101 diet). The observed progeroid phenotype does not seem to be due to general sickness or developmental defects, and other signs of premature ageing are observed (reproductive decline, smaller total brood, lipofuscin accumulation, pharyngeal muscle degeneration, decrease in pharyngeal pumping and movement).
% change in avg or median lifespan
Mean lifespan is approximately 40% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Transgenic overexpression of ALH-6 extends lifespan in worms fed a standard E. coli OP50 diet, but not when fed HT115. A diet-dependent effect can also be seen when ALH-6 is inpaired through mutations, suggesting that ALH-6 offers an adaptive response promoting survival on particular diets.
    % change in max lifespan
    Maximum lifespan is approximately 20% higher.
    % change in avg or median lifespan
    Mean lifespan is approximately 20% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenDR gene manipulations
      • This gene is present as alh-6

      Homologs in other organisms

      Danio rerio
      aldh4a1
      Drosophila melanogaster
      P5CDh1
      Homo sapiens
      ALDH4A1
      Mus musculus
      Aldh4a1
      Rattus norvegicus
      Aldh4a1
      Saccharomyces cerevisiae
      PUT2
      Schizosaccharomyces pombe
      SPBC24C6.04

      External links

      WormBase
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      Ensembl
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      Entrez Gene
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      Homologues
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      UniProt
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      Internet
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