Caenorhabditis elegansGenAge entry for klf-1 (Caenorhabditis elegans)

Gene information (ID: 1970)

Symbol
klf-1
Name
Kruppel-Like Factor (zinc finger protein)
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Ectopic expression of klf-1 in worms, performed in a transgenic line carrying an intestine-specific construct and resulting in a modest level of overexpression, extends lifespan by approximately 15%. This effect is wwp-1 dependent.
% change in avg or median lifespan
Lifespan is 15% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenDR gene manipulations
    • This gene is present as klf-1
    • A homolog of this gene for Saccharomyces cerevisiae is present as MSN4

    Homologs in other organisms

    Danio rerio
    sp5l
    Drosophila melanogaster
    rn
    Rattus norvegicus
    Klf16
    Saccharomyces cerevisiae
    MSN4

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (175404)
    Homologues
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    UniProt
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    Internet
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