Caenorhabditis elegansGenAge entry for dagl-2 (Caenorhabditis elegans)

Gene information (ID: 1930)

Symbol
dagl-2
Name
DiAcylGlycerol Lipase homolog
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Overexpression of dagl-2 (an ortholog of the fly inaE) extends mean lifespan by up to 13%. Conversely, RNA interference of dagl-2 results in a lifespan decrease of up to 14%, while loss-of-function mutantions result in a shorten lifespan by up to 20%.
% change in avg or median lifespan
Mean lifespan is up to 13% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Drosophila melanogaster is present as inaE

    Homologs in other organisms

    Danio rerio
    CT030046.1
    Drosophila melanogaster
    inaE
    Homo sapiens
    DAGLA
    Mus musculus
    Dagla
    Rattus norvegicus
    Dagla

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (3565075)
    Homologues
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    UniProt
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    Internet
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