Drosophila melanogasterGenAge entry for inaE (Drosophila melanogaster)

Gene information (ID: 1928)

Symbol
inaE
Name
inactivation no afterpotential E
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Fly mutants (EP-element insertion), exhibiting up-regulation of DAGL, display extended lifespan (mean is 72% higher) and enhanced oxidative stress response. Complementarily, mutants exhibiting down-regulation of DAGL have a shortened lifespan (mean is 50% lower) and reduced oxidative stress resistance. Additionally, transgenic overexpression of DAGL results in increased mean lifespan (up to 41%).
% change in avg or median lifespan
Mean lifespan is 73% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as dagl-2

    Homologs in other organisms

    Caenorhabditis elegans
    CELE_F42G9.6
    Danio rerio
    CT030046.1
    Homo sapiens
    DAGLA
    Mus musculus
    Dagla
    Rattus norvegicus
    Dagla

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (32343)
    Homologues
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    UniProt
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    Internet
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