Mus musculusGenAge entry for Rictor (Mus musculus)

Gene information (ID: 1852)

Symbol
Rictor
Name
RPTOR independent companion of MTOR, complex 2
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Heterozygous male rictor+/- mice display a significantly decrease in median lifespan (40%) compared to wild-type controls. Liver- specific deletion of Rictor in male mice also resulted in a 30% decrease in median lifespan. In both models, the decrease in lifespan was associated by a decrease in the incidence of cancer. Inducibly deleting Rictor throughout the body in adult animals, results in a stronger phenotype with a median survival of less than 1 year. No significant changes were observed for female lifespan in any of the three models.
% change in avg or median lifespan
Median lifespan of Rictor-deficient mice was up to 40% lower in males. Lifespan was not affected in females.
Lifespan Effect
Decrease
Genetic Manipulation
Depletion
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as rict-1
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as RICTOR
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as RICTOR

    Homologs in other organisms

    Caenorhabditis elegans
    rict-1
    Danio rerio
    rictorb
    Drosophila melanogaster
    rictor
    Homo sapiens
    RICTOR
    Rattus norvegicus
    Rictor
    Saccharomyces cerevisiae
    TSC11
    Schizosaccharomyces pombe
    ste16

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (78757)
    Homologues
    Search HomoloGene
    UniProt
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    Internet
    Search Google or Search Google Scholar