Mus musculusGenAge entry for Ercc1 (Mus musculus)

Gene information (ID: 1850)

Symbol
Ercc1
Name
excision repair cross-complementing rodent repair deficiency, complementation group 1
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Mutations in the ERCC1 (resulting in a complete knock out or a truncated protein), result in a greatly reduced lifespan (less severe for the truncation) and severe signs of premature ageing: runting, abnormalities of liver nuclei, absence of subcutaneous fat, early onset of ferritin deposition in the spleen, kidney malfunction, gross abnormalities of ploidy and cytoplasmic invaginations in nuclei of liver and kidney, and compromised NER and cross-link repair. Additionally, ERCC1-mutant cells undergo premature replicative senescence.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Hypomorphic ERCC1 mice (hemizygous for a single truncated Ercc1 allele, encoding protein lacking seven amino acids) have a decreased median and maximum lifespan, and display symptoms of premature aging, including decline in weight of both whole body and various organs, numerous histopathological lesions, and immune parameters.
    % change in max lifespan
    Maximum lifespan is 83% lower in males and 80% lower in females.
    % change in avg or median lifespan
    Median lifespan is 83% lower in males and 82% lower in females.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Mutation
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as ERCC1
      LongevityMap
      • A homolog of this gene for Homo sapiens is present as ERCC1

      Homologs in other organisms

      Caenorhabditis elegans
      ercc-1
      Danio rerio
      ercc1
      Drosophila melanogaster
      Ercc1
      Homo sapiens
      ERCC1
      Rattus norvegicus
      Ercc1
      Schizosaccharomyces pombe
      swi10

      External links

      Mouse Genome Informatics
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (13870)
      Homologues
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      UniProt
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      Internet
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