Drosophila melanogasterGenAge entry for SNF1A (Drosophila melanogaster)

Gene information (ID: 1846)

Symbol
SNF1A
Aliases
ampk; AMPK; ampkalpha; AMPKalpha; CG3051; dAMPKa; dAMPKa
Name
SNF1A/AMP-activated protein kinase
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Transgenic expression of AMPK in adult fat body or adult muscle, key metabolic tissues, extended life span, while AMPK RNAi reduced life span. Supplementing adenine, a substrate for AMP biosynthesis, to the diet of long-lived AMP biosynthesis mutants reversed life span extension.
Lifespan Effect
Not Recorded
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Transgenic expression of AMPK in adult fat body or adult muscle, key metabolic tissues, extended life span, while AMPK RNAi reduced life span. Supplementing adenine, a substrate for AMP biosynthesis, to the diet of long-lived AMP biosynthesis mutants reversed life span extension.
    Lifespan Effect
    Not Recorded
    Genetic Manipulation
    RNA interference
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      Adult-onset, neuron-specific upregulation of the catalytic alpha AMPK subunit results in increased median lifespan in female flies and has variable effects on male lifespan. This longevity effect is dependent on Atg1 gene activity.
      % change in avg or median lifespan
      Median lifespan is up to 20% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      Overexpression
      Longevity Category
      Pro-Longevity
      Primary reference

        In other databases

        GenAge model organism genes
        • A homolog of this gene for Caenorhabditis elegans is present as aak-2
        • A homolog of this gene for Saccharomyces cerevisiae is present as SNF1
        GenDR gene manipulations
        • A homolog of this gene for Caenorhabditis elegans is present as aak-2
        CellAge
        • A homolog of this gene for Homo sapiens is present as CHEK1

        Homologs in other organisms

        Caenorhabditis elegans
        aak-2
        Danio rerio
        prkaa1
        Homo sapiens
        CHEK1
        Mus musculus
        Prkaa1
        Rattus norvegicus
        Prkaa1
        Saccharomyces cerevisiae
        SNF1
        Schizosaccharomyces pombe
        ssp2

        External links

        FlyBase
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (43904)
        Homologues
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        UniProt
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        Internet
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