Drosophila melanogasterGenAge entry for Mpk2 (Drosophila melanogaster)

Gene information (ID: 1832)

Symbol
Mpk2
Aliases
CG5475; D-MPK2; D-p38; D-p38; MAPK; D-p38a; D-P38a; Dmel\
Name
CG5475-PA
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
p38K-DKO adult flies appeared normal on eclosion but had a severely reduced lifespan. ingle mutants of p38Ka (p38Kadel) or p38Kb (p38Kd45) also had significantly reduced lifespan, with the loss of p38Kb resulting in a stronger phenotype.
% change in avg or median lifespan
Average lifespan is 40% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenDR gene manipulations
    • A homolog of this gene for Schizosaccharomyces pombe is present as sty1

    Homologs in other organisms

    Caenorhabditis elegans
    pmk-1
    Danio rerio
    mapk11
    Homo sapiens
    MAPK11
    Mus musculus
    Mapk11
    Rattus norvegicus
    Mapk11
    Saccharomyces cerevisiae
    HOG1
    Schizosaccharomyces pombe
    sty1

    External links

    FlyBase
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (42866)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar