Mus musculusGenAge entry for Ncor2 (Mus musculus)

Gene information (ID: 1815)

Symbol
Ncor2
Aliases
SMRT; N-CoR; SMRTe
Name
nuclear receptor co-repressor 2
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
In older animals, SMRTmRID1 mice developed cataracts, alopecia and gray hair sooner than wt controls. In addition, the rotarod test demonstrated that SMRTmRID1 mice had diminished sensorimotor coordination, implicating a premature aging phenotype. SMRTmRID1 mice had elevated levels of fasting serum triglycerides, cholesterol, glucose, insulin and leptin as well as reduced adiponectin concentrations, compared to control animals. Kaplan-Meier survival curves showed that both female (p=0.028) and male (p=0.012) SMRTmRID1 mice had shortened lifespan.
% change in avg or median lifespan
Average lifespan is 30-50% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as NCOR2

    Homologs in other organisms

    Danio rerio
    ncor2
    Drosophila melanogaster
    Smr
    Homo sapiens
    NCOR2
    Rattus norvegicus
    Ncor2

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (20602)
    Homologues
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    UniProt
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    Internet
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