Mus musculusGenAge entry for Mtor (Mus musculus)

Gene information (ID: 1809)

Symbol
Mtor
Aliases
FRAP; flat; FRAP2; Frap1; RAFT1; RAPT1; AI327068; 2610315
Name
mechanistic target of rapamycin (serine/threonine kinase)
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Mice hypomorphic for mTor have reduced mTor expression, are smaller and live about 20% longer.
% change in avg or median lifespan
Average lifespan is 20% higher.
Lifespan Effect
Increase
Genetic Manipulation
Genetic reduction
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as let-363
    • A homolog of this gene for Drosophila melanogaster is present as Tor
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as MTOR
    GenDR gene manipulations
    • A homolog of this gene for Caenorhabditis elegans is present as let-363
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as MTOR

    Homologs in other organisms

    Caenorhabditis elegans
    let-363
    Danio rerio
    mtor
    Drosophila melanogaster
    Tor
    Homo sapiens
    MTOR
    Rattus norvegicus
    Mtor
    Saccharomyces cerevisiae
    TOR2
    Schizosaccharomyces pombe
    tor2

    External links

    Mouse Genome Informatics
    Search
    Ensembl
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    Entrez Gene
    View on Entrez Gene database (56717)
    Homologues
    Search HomoloGene
    UniProt
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    Internet
    Search Google or Search Google Scholar