Mus musculusGenAge entry for Htra2 (Mus musculus)

Gene information (ID: 1802)

Symbol
Htra2
Aliases
Omi; mnd2; Prss25; AI481710
Name
HtrA serine peptidase 2
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Mice with both a mutation in Htra2 (which normally causes neurodegeneration 30-40 days after birth) and expressing human HTRA2 in the central nervous system (which rescues mice from neurodegeneration and prevents premature death) develop signs of premature ageing. These include premature weight loss, hair loss, reduced fertility and kyphosis.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as HTRA2

    Homologs in other organisms

    Danio rerio
    uncharacterized_F1RE
    Drosophila melanogaster
    HtrA2
    Homo sapiens
    HTRA2
    Rattus norvegicus
    Htra2

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (64704)
    Homologues
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    UniProt
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    Internet
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