Mus musculusGenAge entry for Eif5a2 (Mus musculus)

Gene information (ID: 1794)

Symbol
Eif5a2
Aliases
eIF5AII; 9630038B20
Name
eukaryotic translation initiation factor 5A2
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Overexpression of Eif5a2 in mice results in accumulation of chromosomal instability and features resembling accelerated ageing, including a short lifespan (average lifespan of about 8 months), kyphosis, osteoporosis, delay of wound healing and ossification.
Lifespan Effect
Decrease
Genetic Manipulation
Overexpression
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as iff-1
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as EIF5A2

    Homologs in other organisms

    Caenorhabditis elegans
    iff-1
    Drosophila melanogaster
    eIF-5A
    Homo sapiens
    EIF5A2
    Rattus norvegicus
    Eif5a2
    Saccharomyces cerevisiae
    ANB1
    Schizosaccharomyces pombe
    tif51b

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (208691)
    Homologues
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    UniProt
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    Internet
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