Caenorhabditis elegansGenAge entry for mfn-1 (Caenorhabditis elegans)

Gene information (ID: 1750)

Symbol
mfn-1
Name
Protein MFN-1
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Reduction of mitoferrin through RNAi results in small body size, reduced fecundity, slow movement and increased sensitivity to paraquat, but also in an increased lifespan of 50% to 80% compared to the N2 wild type worms strain.
% change in max lifespan
Maximum lifespan is up to 77% higher.
% change in avg or median lifespan
Average lifespan is up to 64% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as MRS4

    Homologs in other organisms

    Danio rerio
    slc25a37
    Drosophila melanogaster
    mfrn
    Homo sapiens
    SLC25A28
    Mus musculus
    Slc25a28
    Rattus norvegicus
    Slc25a28
    Saccharomyces cerevisiae
    MRS4
    Schizosaccharomyces pombe
    SPAC8C9.12c

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (174752)
    Homologues
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    UniProt
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    Internet
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