Saccharomyces cerevisiaeGenAge entry for TOP1 (Saccharomyces cerevisiae)

Gene information (ID: 1547)

Symbol
TOP1
Aliases
MAK1; MAK17
Name
TOPoisomerase
Organism
Saccharomyces cerevisiae (AnAge)

Potential relevance to longevity and/or ageing

Observations
Replicative lifespan decreased by 60% in the alpha strain
% change in avg or median lifespan
Replicative lifespan is 60% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Deletion
Longevity Category
Necessary for fitness
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as top-1

    Homologs in other organisms

    Caenorhabditis elegans
    top-1
    Danio rerio
    top1
    Drosophila melanogaster
    Top1
    Homo sapiens
    TOP1MT
    Mus musculus
    Top1mt
    Rattus norvegicus
    Top1mt
    Schizosaccharomyces pombe
    top1

    External links

    Saccharomyces Genome Database
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (854156)
    Homologues
    Search HomoloGene
    UniProt
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    Internet
    Search Google or Search Google Scholar