Caenorhabditis elegansGenAge entry for zfh-2 (Caenorhabditis elegans)

Gene information (ID: 1823)

Symbol
zfh-2
Name
Protein ZFH-2
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Several of the RNAi candidates (dve-1; lin-40; nhr-49; ceh-20; lin-11; and nhr-77) appeared to non-discriminately shorten lifespan in all strains tested, suggesting that the corresponding transcription factors are broadly required for survival. Interestingly, four RNAi clones (ZC123.3; nhr-119; ceh-37; and aha-1) affected wild-type and isp-1;ctb-1 mutant worms' lifespan to the same extent but exerted only a moderate or no effect on daf-16 and age-1 mutant longevity.
% change in avg or median lifespan
Average lifespan is 45% lower.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    si:ch73-386h18.1
    Drosophila melanogaster
    zfh2
    Homo sapiens
    ZFHX2
    Mus musculus
    Zfhx2
    Rattus norvegicus
    Zfhx3

    External links

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    Entrez Gene
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    Homologues
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    Internet
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