Caenorhabditis elegansGenAge entry for wwp-1 (Caenorhabditis elegans)

Gene information (ID: 733)

Symbol
wwp-1
Name
WW domain Protein (E3 ubiquitin ligase)
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Ubiquitin-protein ligase

Potential relevance to longevity and/or ageing

Observations
RNA interference of wwp-1 results in reduced lifespan at 25 degrees (but not at 20 degrees). Transgenic overexpression of wwp-1 results in a 20% increase in lifespan.
% change in avg or median lifespan
Lifespan is 20% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    RNA interference decreased median lifespan by 9% in wild type animals and 24% in daf-2 mutants.
    % change in avg or median lifespan
    Median lifespan is 9% lower.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    RNA interference
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenDR gene manipulations
      • This gene is present as wwp-1

      Homologs in other organisms

      Danio rerio
      wwp2
      Drosophila melanogaster
      Su(dx)
      Homo sapiens
      ITCH
      Mus musculus
      Itch
      Rattus norvegicus
      Itch
      Saccharomyces cerevisiae
      RSP5
      Schizosaccharomyces pombe
      pub1

      External links

      WormBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (171647)
      Homologues
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      UniProt
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      Internet
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