Caenorhabditis elegansGenAge entry for vhl-1 (Caenorhabditis elegans)

Gene information (ID: 998)

Symbol
vhl-1
Name
von Hippel-Lindau tumor suppressor homolog
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Loss of VHL-1 significantly increased average lifespan (by 30%) and enhanced resistance to polyglutamine and amyloid beta toxicity, no change in MLS
% change in avg or median lifespan
Average lifespan is 30% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Loss of vhl-1 significantly increased lifespan and resulted in accelerated basal signaling of the p38 mitogen-activated protein kinase PMK-3.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference

      Homologs in other organisms

      Drosophila melanogaster
      Vhl

      External links

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