Caenorhabditis elegansGenAge entry for vang-1 (Caenorhabditis elegans)

Gene information (ID: 1752)

Symbol
vang-1
Name
Protein VANG-1
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Vang-1 mutations as well as RNAi depletion result in an increased mean lifespan in a DAF-16 dependent manner. The longevity phenotype is accompanied by enhanced resistance to thermal- and oxidative stress and decreased lipofuscin accumulation. Mutants also have a smaller brood size, decreased ovulation rate and prolonged reproductive span.
% change in avg or median lifespan
Average lifespan is up to 40% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference and/or mutations
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    vangl2
    Drosophila melanogaster
    Vang
    Homo sapiens
    VANGL2
    Mus musculus
    Vangl2
    Rattus norvegicus
    Vangl2

    External links

    WormBase
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    Entrez Gene
    View on Entrez Gene database (180579)
    Homologues
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    UniProt
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    Internet
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