Caenorhabditis elegansGenAge entry for utx-1 (Caenorhabditis elegans)

Gene information (ID: 1749)

Symbol
utx-1
Name
Protein UTX-1
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
RNAi of the utx-1 gene extended the mean life span of worms, dependent on DAF-16 activity and not additive in daf-2 mutants. The loss of utx-1 increased H3K27me3 on the Igf1r/daf-2 gene and decreased IIS activity, resulting into an epigenetic state closer to that of younger worms.
% change in avg or median lifespan
Average lifespan is aproximately 30% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    RNA inteference of utx-1 results in an incrased lifespan of up to 19%, depending on temperature.
    % change in avg or median lifespan
    Mean lifespan is 19% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference

      Homologs in other organisms

      Danio rerio
      kdm6al
      Drosophila melanogaster
      Utx
      Homo sapiens
      KDM6B
      Mus musculus
      Kdm6b
      Rattus norvegicus
      Kdm6a

      External links

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      Entrez Gene
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      Internet
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