Caenorhabditis elegansGenAge entry for ttx-1 (Caenorhabditis elegans)

Gene information (ID: 1741)

Symbol
ttx-1
Name
Protein TTX-1
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Animals in which the thermosensory AFD neurons had been laser ablated, as well as animals that carry ttx-1 mutations, live up to 25% shorter than normal at 25 degrees C, a warm temperature, but neither AFD ablation nor ttx-1 mutation do not influence life span at 15 or 20 degrees C.
% change in avg or median lifespan
Lifespan is up to 25% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    otx1a
    Drosophila melanogaster
    Gsc
    Homo sapiens
    CRX
    Mus musculus
    Crx

    External links

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    Entrez Gene
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    Homologues
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    UniProt
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    Internet
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