Caenorhabditis elegansGenAge entry for ttm-5 (Caenorhabditis elegans)

Gene information (ID: 1921)

Symbol
ttm-5
Name
Putative sphingolipid delta(4)-desaturase/C4-hydroxylase
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
RNA interference of TTM-5 (Y54E5A.1), an ortholog of human delta(4)-desaturase, sphingolipid 2, results in both mean and maximum lifespan extension.
% change in max lifespan
Maximum lifespan is 12% higher.
% change in avg or median lifespan
Mean lifespan is 40% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    degs1
    Drosophila melanogaster
    ifc
    Homo sapiens
    DEGS1
    Mus musculus
    9130409I23Rik
    Rattus norvegicus
    RGD1564463

    External links

    WormBase
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (173327)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar