Caenorhabditis elegansGenAge entry for tmem-135 (Caenorhabditis elegans)

Gene information (ID: 992)

Symbol
tmem-135
Name
K02G10.3
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Deletion of the tmem135 orthologue in C. elegans caused a 41.8% (62.8%) reduction in fat stores, a reduction in mitochondrial action potential and decreased longevity of the worm. In stark contrast, C. elegans transgenic animals overexpressing TMEM-135 exhibited increased longevity upon exposure to cold stress.
Lifespan Effect
Decrease
Genetic Manipulation
Deletion
Primary reference

    Homologs in other organisms

    Danio rerio
    tmem135
    Drosophila melanogaster
    CG31454
    Homo sapiens
    TMEM135
    Mus musculus
    Tmem135
    Rattus norvegicus
    Tmem135

    External links

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    Entrez Gene
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    Homologues
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    UniProt
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    Internet
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