Caenorhabditis elegansGenAge entry for tatn-1 (Caenorhabditis elegans)

Gene information (ID: 2008)

Symbol
tatn-1
Name
Tyrosine AminoTraNsferase
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Worms with tatn-1 mutations (baf1, partial loss-of-function), impairing tyrosine aminotransferase activity, show elevated levels of tyrosine, are prone to arresting development in dauer stage, and display increased longevity compared to wild type N2 controls (mean lifespan ~10% longer). Similar effects were observed for worms which have tatn-1 inhibited by RNA interference (~9%). Additionally, tatn-1 mutations or RNA interference also extend the lifespan of the eak7 (by ~12%) and daf-2 (by ~21%) long-lived mutants. The longevity extension effect of tatn-1 is dependent on aak-2 and daf-16 independent.
% change in avg or median lifespan
Mean lifespan is approximately 10% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    tat
    Drosophila melanogaster
    CG1461
    Homo sapiens
    TAT
    Mus musculus
    Tat
    Rattus norvegicus
    Tat

    External links

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