Caenorhabditis elegansGenAge entry for spl-1 (Caenorhabditis elegans)

Gene information (ID: 626)

Symbol
spl-1
Name
Sphingosine Phosphate Lyase
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Sphingosine phosphate lyase

Potential relevance to longevity and/or ageing

Observations
RNA interference decreased median lifespan by 22% in wild type animals, 63% in a daf-2 background and 17% in daf-2/daf-16 double mutants.
% change in avg or median lifespan
Median lifespan is 22% lower.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Homo sapiens
    SGPL1
    Mus musculus
    Sgpl1
    Rattus norvegicus
    Sgpl1
    Saccharomyces cerevisiae
    DPL1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (176857)
    Homologues
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    UniProt
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    Internet
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