Caenorhabditis elegansGenAge entry for sod-2 (Caenorhabditis elegans)

Gene information (ID: 985)

Symbol
sod-2
Name
Superoxide dismutase (24.5 kD) (sod-2)
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Treatment of wild-type worms increased their mean LS by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their LS (a 67 percent increase).
% change in avg or median lifespan
Average lifespan is 44% higher.
Lifespan Effect
Increase
Genetic Manipulation
Pharmacological overexpression (Superoxide dismutase/catalase mimetics)
Longevity Category
Pro-Longevity
Primary reference
    Observations
    sod-2 mutants are long-lived (maximum lifespan increased by 30%) despite a significant increase in oxidatively damaged proteins. The lifespan of sod1, sod3, sod4 and sod5 mutants was not affected. Examination of worm lifespan revealed that sod-1; sod-3; sod-5 mutant worms live as long as wild-type worms while both sod-2; sod-3; sod-5 and sod-1; sod-2; sod- 4 mutant worms live significantly longer than wild-type (maximum lifespan increased by 30%).
    % change in max lifespan
    Maximum lifespan is 30% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Mutations
    Longevity Category
    Anti-Longevity
    Primary reference

      Homologs in other organisms

      No homologs found

      External links

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      Entrez Gene
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      Homologues
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      Internet
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