Caenorhabditis elegansGenAge entry for smn-1 (Caenorhabditis elegans)

Gene information (ID: 617)

Symbol
smn-1
Name
SMN (human Survival Motor Neuron gene) homolog
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
mRNA splicing protein

Potential relevance to longevity and/or ageing

Observations
RNA interference results in a 40% decrease in median lifespan in daf-2 mutants, 13% decrease in lifespan in daf-2/daf-16 double mutants and a 26% decrease in median lifespan in a wild-type background.
% change in avg or median lifespan
Median lifespan is 26% lower.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    smn1
    Homo sapiens
    SMN1
    Mus musculus
    Smn1
    Rattus norvegicus
    Smn1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (172783)
    Homologues
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    UniProt
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    Internet
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