Caenorhabditis elegansGenAge entry for smk-1 (Caenorhabditis elegans)

Gene information (ID: 616)

Symbol
smk-1
Name
suppressor of MEK null
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Stress response

Potential relevance to longevity and/or ageing

Observations
RNA interference of smk-1 completely suppressed the extended longevity of daf-2 mutations and partly the life-extension of clk-1 mutants. It only slightly shortened the lifespan of wild-type worms.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference
    Observations
    RNAi led to a 44% decrease in median lifespan in daf-2 background and 21% decrease in lifespan in wild-type background.
    % change in avg or median lifespan
    Lifespan is 21% lower.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    RNA interference
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenDR gene manipulations
      • This gene is present as smk-1

      Homologs in other organisms

      Danio rerio
      CABZ01031887.1
      Drosophila melanogaster
      flfl
      Homo sapiens
      SMEK3P
      Mus musculus
      4932429P05Rik
      Rattus norvegicus
      Smek3
      Saccharomyces cerevisiae
      PSY2
      Schizosaccharomyces pombe
      SPBC216.01c

      External links

      WormBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (179243)
      Homologues
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      UniProt
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      Internet
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