Caenorhabditis elegansGenAge entry for skr-2 (Caenorhabditis elegans)

Gene information (ID: 614)

Symbol
skr-2
Name
SKp1 Related (ubiquitin ligase complex component)
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
SKp1 Related (ubiquitin ligase complex component)

Potential relevance to longevity and/or ageing

Observations
RNA interference in adulthood of skr-1 and skr-2 shortened the extended lifespan of daf-2(mu150) mutants by up to 44%. No effect in the lifespan of wild-type worms or in the extended lifespans of glp-1(e2141ts) or eat-2(ad1116) mutants was observed.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    skp1
    Drosophila melanogaster
    skpB
    Homo sapiens
    SKP1
    Mus musculus
    Skp1
    Rattus norvegicus
    Skp1

    External links

    WormBase
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    Entrez Gene
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    Homologues
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    UniProt
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    Internet
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