Caenorhabditis elegansGenAge entry for sesn-1 (Caenorhabditis elegans)

Gene information (ID: 1878)

Symbol
sesn-1
Name
Sestrin homolog
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Mutant SESN-1 worms (ok3157 or tm2827) show a decrease in lifespan at both 20C and 25C (up to 46%). Similarly, RNAi of SESN-1 also decreases lifespan (up to 31%).
% change in avg or median lifespan
Median lifespan is up to 46% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Overexpressing SESN-1 results in an increase lifespan compared to wild-types (by up to 16%). Additionally, expression of the SESN-1 gene can also rescue the phenotype of short-lived SESN-1 mutants.
    % change in avg or median lifespan
    Median lifespan is up to 16% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference

      Homologs in other organisms

      Danio rerio
      CABZ01047562.1
      Drosophila melanogaster
      Sesn
      Homo sapiens
      SESN3
      Mus musculus
      Sesn2
      Rattus norvegicus
      Sesn1

      External links

      WormBase
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      Entrez Gene
      View on Entrez Gene database (171593)
      Homologues
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      UniProt
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      Internet
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