Caenorhabditis elegansGenAge entry for rps-15 (Caenorhabditis elegans)

Gene information (ID: 567)

Symbol
rps-15
Name
Ribosomal Protein, Small subunit
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Ribosomal Protein, Small subunit

Potential relevance to longevity and/or ageing

Observations
RNA interference of rps-15 results in an increased lifespan.
% change in avg or median lifespan
Mean lifespan is 9.7% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    RNA interference in young adults reducing mRNA levels approximately two- to fivefold increased median lifespan 10-50% and maximum lifespan by about 40%. A life-extending effect was also observed in daf-16 mutants and sir-2.1 mutants but not in daf-2 mutants. TOR RNA interference further extended lifespan.
    % change in max lifespan
    Maximum lifespan is about 40% higher.
    % change in avg or median lifespan
    Median lifespan is 10-50% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference

      Homologs in other organisms

      Danio rerio
      rps15
      Drosophila melanogaster
      RpS15
      Homo sapiens
      RPS15
      Mus musculus
      Rps15
      Rattus norvegicus
      LOC100360484
      Saccharomyces cerevisiae
      RPS15
      Schizosaccharomyces pombe
      rps15a

      External links

      WormBase
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      Entrez Gene
      View on Entrez Gene database (172693)
      Homologues
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      UniProt
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      Internet
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