Caenorhabditis elegansGenAge entry for rps-11 (Caenorhabditis elegans)

Gene information (ID: 566)

Symbol
rps-11
Name
Ribosomal Protein, Small subunit
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
40S subunit of the ribosome

Potential relevance to longevity and/or ageing

Observations
Knockdown of rps-11 increased lifespan.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    RNA interference of rps-11 results in an increased lifespan.
    % change in avg or median lifespan
    Mean lifespan is 29.8% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      Post developmental RNAi let to a 25% increase in maximum lifespan of sterile animals.
      % change in max lifespan
      Maximum lifespan is 25% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      RNA interference
      Longevity Category
      Anti-Longevity
      Primary reference
        Observations
        RNA interference in adulthood extended mean lifespan by 28%.
        % change in avg or median lifespan
        Average lifespan is 28% higher.
        Lifespan Effect
        Increase
        Genetic Manipulation
        RNA interference
        Longevity Category
        Anti-Longevity
        Primary reference

          Homologs in other organisms

          Danio rerio
          si:dkey-159f12.2
          Drosophila melanogaster
          RpS11
          Homo sapiens
          RPS11
          Mus musculus
          Rps11
          Rattus norvegicus
          RGD1565560
          Saccharomyces cerevisiae
          RPS11A
          Schizosaccharomyces pombe
          rps11a

          External links

          WormBase
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          Entrez Gene
          View on Entrez Gene database (178083)
          Homologues
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          UniProt
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          Internet
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