Caenorhabditis elegansGenAge entry for rle-1 (Caenorhabditis elegans)

Gene information (ID: 552)

Symbol
rle-1
Name
Regulation of Longevity by E3 ubiquitin ligase
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
E3 ubiquitin ligase

Potential relevance to longevity and/or ageing

Observations
Disruption of rle-1 extended maximum lifespan by about 30%, dependent on daf-16 since disruption of daf-16 in rle-1 mutants reversed the life-extending effects. Overexpression of daf-16 in rle-1 mutants further increased lifespan. Disrupted of rle-1 also resulted in partial embryonic lethality and fewer progeny.
% change in max lifespan
Maximum lifespan is about 30% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    rc3h2
    Homo sapiens
    RC3H2
    Mus musculus
    Rc3h1
    Rattus norvegicus
    Rc3h2

    External links

    WormBase
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (176525)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar