Drosophila melanogasterGenAge entry for rdgA (Drosophila melanogaster)

Gene information (ID: 1929)

Symbol
rdgA
Name
retinal degeneration A
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Knockdown of rdgA in flies results in increased mean lifespan by up to 44%. Similarly, rdgA mutants display increased mean lifespans of up to 53%. Simultaneous overexpression of DAGL (known lifespan extension intervention) and rdgA knockdown do not further extend lifespan of that achieved by either manipulation independently, suggesting the two interventions work through similar mechanisms.
% change in avg or median lifespan
Mean lifespan is up to 44% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as dgk-5

    Homologs in other organisms

    Caenorhabditis elegans
    dgk-5
    Danio rerio
    dgki
    Homo sapiens
    DGKZ
    Mus musculus
    Dgkz
    Rattus norvegicus
    Dgkz

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (31826)
    Homologues
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    UniProt
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    Internet
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