Caenorhabditis elegansGenAge entry for rbr-2 (Caenorhabditis elegans)

Gene information (ID: 976)

Symbol
rbr-2
Name
RB (Retinoblastoma Binding protein) Related
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Previously, the rbr-2(tm1231) strain has been reported to display reduced longevity, and overexpression of rbr-2 can extend lifespan of adult wild-type animals at 20 degrees (Greer et al., 2010). In contrast, the ok2544 rbr-2 mutation exhibits longer mean and maximum lifespan, both at 20 (~14%) and 25 (~15%) degrees.
% change in avg or median lifespan
Mean lifespan is approximately 15% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference
    Observations
    RNA inteference of rbr-2 results in an incrased lifespan of up to 37%, depending on temperature.
    % change in avg or median lifespan
    Mean lifespan is 37% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      25% mean lifespan decrease
      % change in avg or median lifespan
      Average lifespan is 25% lower.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      Mutations
      Longevity Category
      Pro-Longevity
      Primary reference

        Homologs in other organisms

        Danio rerio
        uncharacterized_H9GX
        Drosophila melanogaster
        lid
        Homo sapiens
        KDM5C
        Mus musculus
        Kdm5d
        Rattus norvegicus
        Kdm5c
        Schizosaccharomyces pombe
        msc1

        External links

        WormBase
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (177985)
        Homologues
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        UniProt
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        Internet
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