Caenorhabditis elegansGenAge entry for rab-5 (Caenorhabditis elegans)

Gene information (ID: 975)

Symbol
rab-5
Name
RAB family
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Post-developmental RNAi of rab-5 shortens lifespan of wild type worms.
% change in max lifespan
Maximum lifespan is 50% lower.
% change in avg or median lifespan
Average lifespan is 38% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Post-developmental RNA interference
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Mean LS reduced by 50% compared to WT
    % change in avg or median lifespan
    Average lifespan is 50% lower.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    RNA interference
    Longevity Category
    Pro-Longevity
    Primary reference

      Homologs in other organisms

      Danio rerio
      rab5c
      Drosophila melanogaster
      Rab5
      Homo sapiens
      RAB5C
      Mus musculus
      Rab5b
      Rattus norvegicus
      Rab5b
      Saccharomyces cerevisiae
      YPT53
      Schizosaccharomyces pombe
      ypt5

      External links

      WormBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (172755)
      Homologues
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      UniProt
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      Internet
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