Caenorhabditis elegansGenAge entry for pept-1 (Caenorhabditis elegans)

Gene information (ID: 482)

Symbol
pept-1
Name
OligoPeptide Transporter
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Intestinal peptide transporter

Potential relevance to longevity and/or ageing

Observations
Gene inactivation of nhx-2 by RNAi led to a loss of fat stores in the intestine and a 40% increase in longevity while double RNAi of nhx-2 and opt-2 led to 10-20% increase in longevity
% change in avg or median lifespan
Lifespan is 40% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Deletion of pept1 (also called opt-2, pep-2) results in retarded development, reduced body size and extended reproductive lifespan. It also further extends (60%) the life-extension caused by daf-2 mutations.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Deletion
    Longevity Category
    Anti-Longevity
    Primary reference

      Homologs in other organisms

      Danio rerio
      slc15a1a
      Danio rerio
      slc15a1b
      Danio rerio
      slc15a2
      Drosophila melanogaster
      CG2930
      Drosophila melanogaster
      yin
      Homo sapiens
      SLC15A2
      Homo sapiens
      SLC15A1
      Mus musculus
      Slc15a2
      Mus musculus
      Slc15a1
      Rattus norvegicus
      Slc15a2
      Rattus norvegicus
      Slc15a1
      Saccharomyces cerevisiae
      PTR2

      External links

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      Entrez Gene
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      Homologues
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      UniProt
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      Internet
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