Caenorhabditis elegansGenAge entry for pept-1 (Caenorhabditis elegans)

Gene information (ID: 482)

Symbol
pept-1
Name
OligoPeptide Transporter
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Intestinal peptide transporter

Potential relevance to longevity and/or ageing

Observations
Gene inactivation of nhx-2 by RNAi led to a loss of fat stores in the intestine and a 40% increase in longevity while double RNAi of nhx-2 and opt-2 led to 10-20% increase in longevity
% change in avg or median lifespan
Lifespan is 40% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Deletion of pept1 (also called opt-2, pep-2) results in retarded development, reduced body size and extended reproductive lifespan. It also further extends (60%) the life-extension caused by daf-2 mutations.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Deletion
    Longevity Category
    Anti-Longevity
    Primary reference

      Homologs in other organisms

      Drosophila melanogaster
      yin
      Homo sapiens
      SLC15A2
      Rattus norvegicus
      Slc15a2

      External links

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      Entrez Gene
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      Internet
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