Caenorhabditis elegansGenAge entry for pdp-1 (Caenorhabditis elegans)

Gene information (ID: 2065)

Symbol
pdp-1
Name
Pyruvate Dehydrogenase Phosphatase homolog
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Pdp-1 overexpression increases the lifespan of wild-type and daf-2 worms (by 17%), while pdp-1 mutants live slightly shorter than wild-type animals (by 8%).
% change in avg or median lifespan
Mean lifespan is 17% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as PTC5

    Homologs in other organisms

    Danio rerio
    si:ch211-15p9.2
    Drosophila melanogaster
    Pdp
    Homo sapiens
    PDP2
    Mus musculus
    Pdp2
    Rattus norvegicus
    Pdp1
    Saccharomyces cerevisiae
    PTC5
    Schizosaccharomyces pombe
    SPAC10F6.17c

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (172035)
    Homologues
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    UniProt
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    Internet
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