Caenorhabditis elegansGenAge entry for pcm-1 (Caenorhabditis elegans)

Gene information (ID: 969)

Symbol
pcm-1
Name
Protein Carboxymethyltransferase
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Overexpression of PCM-1 increases mean adult hermaphrodite life span by 30%. Dauer larvae with a deletion in the pcm-1 gene had a median life span only one quarter of the wt dauer life span at 20C. pcm-1 mutant larvae respond poorly to a pheromone signal as indicated by the reduced number of dauer larvae formed.
% change in avg or median lifespan
Average lifespan is 30% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression, mutations, deletion
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Drosophila melanogaster is present as Pcmt
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as PCMT1

    Homologs in other organisms

    Danio rerio
    pcmtl
    Drosophila melanogaster
    Pcmt
    Homo sapiens
    PCMT1
    Mus musculus
    Pcmt1
    Rattus norvegicus
    Pcmt1
    Schizosaccharomyces pombe
    pcm2

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (178981)
    Homologues
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    UniProt
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    Internet
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