Caenorhabditis elegansGenAge entry for pch-2 (Caenorhabditis elegans)

Gene information (ID: 1872)

Symbol
pch-2
Name
Putative pachytene checkpoint protein 2
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Overexpression of pch-2 in C. elegans extends lifespan and enhances worm resistance to various stressors. Conversely, RNA interference of pch-2 shortens worm lifespan. The mechanism by which pch-2 modulates worm longevity is tied to functions of the sirtuin family.
% change in max lifespan
Maximum lifespan is 25% higher.
% change in avg or median lifespan
Median lifespan is 22% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as PCH2

    Homologs in other organisms

    Danio rerio
    trip13
    Drosophila melanogaster
    pch2
    Homo sapiens
    TRIP13
    Mus musculus
    Trip13
    Rattus norvegicus
    Trip13
    Saccharomyces cerevisiae
    PCH2

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (174313)
    Homologues
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    UniProt
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    Internet
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