Caenorhabditis elegansGenAge entry for pbs-5 (Caenorhabditis elegans)

Gene information (ID: 1980)

Symbol
pbs-5
Name
Proteasome subunit beta type
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Transgenic overexpression of pbs-5, which leads to increased proteasome content, assembly, and activity in worms, results in extension of animal lifespan (~25%). The lifespan extension was accompanied by lower level of lipofuscin, slightly slower developmental timing and defecation rhythms, and increased capacity to enter the stress-resistant dauer larvae form, but no severe physiologic alterations were observed between mutants and wild type controls. Subsequent knock-down of pbs-5 by RNAi abolished the extended lifespan of pbs-5 overexpressing animals.
% change in avg or median lifespan
Mean lifespan is approximately 25% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    psmb5
    Drosophila melanogaster
    CG31742
    Homo sapiens
    PSMB11
    Mus musculus
    Psmb11
    Rattus norvegicus
    Psmb11
    Saccharomyces cerevisiae
    PRE2
    Schizosaccharomyces pombe
    pts1

    External links

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    Entrez Gene
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