Drosophila melanogasterGenAge entry for park (Drosophila melanogaster)

Gene information (ID: 1843)

Symbol
park
Aliases
CG10523; Dmel\CG10523; Dpark; dpk; SD01679
Name
parkin
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Ubiquitous or neuron-specific up-regulation of Parkin, in adult Drosophila melanogaster, increases both mean and maximum lifespan without reducing reproductive output, physical activity, or food intake. Long-lived Parkin-overexpressing flies display an increase in K48-linked polyubiquitin and reduced levels of protein aggregation during aging.
% change in max lifespan
Female maximum lifespan is 28% higher. Smaller positive effects in male flies.
% change in avg or median lifespan
Female average lifespan is 28% higher. Smaller positive effects in male flies.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    LongevityMap
    • A homolog of this gene for Homo sapiens is present as PRKN

    Homologs in other organisms

    Caenorhabditis elegans
    pdr-1
    Homo sapiens
    PARK2
    Mus musculus
    Park2
    Rattus norvegicus
    Park2

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (40336)
    Homologues
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    UniProt
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    Internet
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