- Symbol
- park
- Aliases
- CG10523; Dmel\CG10523; Dpark; dpk; SD01679
- Name
- parkin
- Organism
- Drosophila melanogaster (AnAge)
- Observations
- Ubiquitous or neuron-specific up-regulation of Parkin, in adult Drosophila melanogaster, increases both mean and maximum lifespan without reducing reproductive output, physical activity, or food intake. Long-lived Parkin-overexpressing flies display an increase in K48-linked polyubiquitin and reduced levels of protein aggregation during aging.
- % change in max lifespan
- Female maximum lifespan is 28% higher. Smaller positive effects in male flies.
- % change in avg or median lifespan
- Female average lifespan is 28% higher. Smaller positive effects in male flies.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- LongevityMap
- A homolog of this gene for Homo sapiens is present as PRKN
- CellAge
- A homolog of this gene for Homo sapiens is present as PRKN
- Caenorhabditis elegans
- pdr-1
- Danio rerio
- park2
- Homo sapiens
- PARK2
- Mus musculus
- Park2
- Rattus norvegicus
- AC135026.1
- Rattus norvegicus
- AABR07001519.1
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (40336)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for park (Drosophila melanogaster)