Caenorhabditis elegansGenAge entry for nuo-6 (Caenorhabditis elegans)

Gene information (ID: 1754)

Symbol
nuo-6
Name
Protein NUO-6
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Nuo-6 mutants show slow embryonic and postembryonic development, slow swimming, slow defecation, slow pumping, a mild increase in embryonic and larval lethality, and a substantial increase in lifespan. Similar results were also obtained using RNAi. While the nuo-6, isp-1 double mutants fail to further increase lifespan, the effect of genetic mutations in one of the two genes is additive to the longevity-increasing effect of RNAi in the other gene.
% change in max lifespan
Maximum lifespan is up to 80% higher.
% change in avg or median lifespan
Average lifespan is up to 73% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference and/or mutations
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    Homo sapiens
    NDUFB4
    Mus musculus
    Ndufb4
    Rattus norvegicus
    Ndufb4l1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (172438)
    Homologues
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    UniProt
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    Internet
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