Caenorhabditis elegansGenAge entry for nnt-1 (Caenorhabditis elegans)

Gene information (ID: 465)

Symbol
nnt-1
Name
Nicotinamide Nucleotide Transhydrogenase
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Nicotinamide nucleotide transhydrogenase

Potential relevance to longevity and/or ageing

Observations
nnt-1 appears to inhibit the growth of gld-1 tumours. RNA interference reduced mean lifespan up to 18% in wild type animals, 20% in daf-2 mutants and 16% in daf-2/gld-1 mutants.
% change in avg or median lifespan
Average lifespan is up to 18% lower.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    nnt
    Homo sapiens
    NNT
    Mus musculus
    Nnt
    Rattus norvegicus
    Nnt

    External links

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    Entrez Gene
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    Homologues
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    UniProt
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    Internet
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