Caenorhabditis elegansGenAge entry for nhr-8 (Caenorhabditis elegans)

Gene information (ID: 1952)

Symbol
nhr-8
Name
Nuclear hormone receptor family member nhr-8
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
NHR-8 mutants display a 28-35% shorter lifespan than their N2 wild-type counterparts. The extent of lifespan reduction 28-35%) is dependant on the cholesterol level in their diet, however lifespan was reduced at all tested concentrations.
% change in avg or median lifespan
Median lifespan is up to 35% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    nr1i2
    Homo sapiens
    NR1I3
    Mus musculus
    Nr1h4
    Rattus norvegicus
    Vdr

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (177551)
    Homologues
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    UniProt
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    Internet
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