GenAge entry for nhr-77 (Caenorhabditis elegans)
Gene information (ID: 1822)
- Protein NHR-77
- Caenorhabditis elegans (AnAge)
Potential relevance to longevity and/or ageing
- Several of the RNAi candidates (dve-1; lin-40; nhr-49; ceh-20; lin-11; and nhr-77) appeared to non-discriminately shorten lifespan in all strains tested, suggesting that the corresponding transcription factors are broadly required for survival. Interestingly, four RNAi clones (ZC123.3; nhr-119; ceh-37; and aha-1) affected wild-type and isp-1;ctb-1 mutant worms' lifespan to the same extent but exerted only a moderate or no effect on daf-16 and age-1 mutant longevity.
- % change in avg or median lifespan
- Average lifespan is 7% lower.
- Lifespan Effect
- Genetic Manipulation
- RNA interference
- Longevity Category
- Primary reference
Homologs in other organisms
No homologs found