Caenorhabditis elegansGenAge entry for nhr-25 (Caenorhabditis elegans)

Gene information (ID: 1828)

Symbol
nhr-25
Name
Protein NHR-25
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Several of the RNAi candidates (dve-1; lin-40; nhr-49; ceh-20; lin-11; and nhr-77) appeared to non-discriminately shorten lifespan in all strains tested, suggesting that the corresponding transcription factors are broadly required for survival. Interestingly, four RNAi clones (ZC123.3; nhr-119; ceh-37; and aha-1) affected wild-type and isp-1;ctb-1 mutant worms' lifespan to the same extent but exerted only a moderate or no effect on daf-16 and age-1 mutant longevity.
% change in avg or median lifespan
Average lifespan is 8% lower.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    nr5a5
    Homo sapiens
    NR5A1
    Mus musculus
    Nr5a1
    Rattus norvegicus
    Nr5a1

    External links

    WormBase
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (181432)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar