Caenorhabditis elegansGenAge entry for mml-1 (Caenorhabditis elegans)

Gene information (ID: 2161)

Symbol
mml-1
Name
Myc and Mondo-Like
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Downregulation of mml-1 in worms decreased median lifespan by 10%. In glp-1 mutants downregulation of mml-1 abolished lifespan extension and median lifespan was 65% lower. In addition mm-1 overexpression was found to modestly (but significantly) extend lifespan of wild type worms.
% change in avg or median lifespan
Median lifespan is 10% lower.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    si:ch1073-189o9.1
    Homo sapiens
    MLXIPL
    Mus musculus
    Mlxipl
    Rattus norvegicus
    Mlxip

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (176050)
    Homologues
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    UniProt
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    Internet
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