GenAge entry for mdl-1 (Caenorhabditis elegans)
Gene information (ID: 1907)
- Caenorhabditis elegans (AnAge)
Potential relevance to longevity and/or ageing
- Daf-2 mutants display an upregulated MDL-1. Deletion of mdl-1 shortens lifespan of wild type worm (up to 16%). Moreover, deletion in long-lived daf-2 mutants shortens lifespan to an even higher degree (up to 32%) suggesting it contributes to the effects of daf-2 on lifespan.
- % change in avg or median lifespan
- Mean lifespan is 16% lower.
- Lifespan Effect
- Genetic Manipulation
- Longevity Category
- Primary reference
Homologs in other organisms
No homologs found