Caenorhabditis elegansGenAge entry for mdl-1 (Caenorhabditis elegans)

Gene information (ID: 1907)

Symbol
mdl-1
Name
MAD-Like
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Daf-2 mutants display an upregulated MDL-1. Deletion of mdl-1 shortens lifespan of wild type worm (up to 16%). Moreover, deletion in long-lived daf-2 mutants shortens lifespan to an even higher degree (up to 32%) suggesting it contributes to the effects of daf-2 on lifespan.
% change in avg or median lifespan
Mean lifespan is 16% lower.
Lifespan Effect
Increase
Genetic Manipulation
Deletion
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    No homologs found

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (180942)
    Homologues
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    UniProt
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    Internet
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